Select Your Country/Region

United States English
中国(大陆) 简体中文
España Español
CIS Русский
日本 日本語
Deutschland Deutsch
Italia Italian
Portugal Português
Philippines Philippines
Europe English
Global (Other country or region) English
All Where to Buy About Chuwi Contact Us Blogs Company News Video Center

A Patient's Guide to Understanding the C-Peptide Test

04 Sep 2025 by Maria L. Collazo-Clavell, M.D.

A Patient's Guide to Understanding the C-Peptide Test

The C-peptide test is a crucial diagnostic tool used to assess the function of the pancreas and diagnose conditions related to blood sugar regulation. As a patient, it's essential to understand the purpose, process, and implications of this test. In this guide, we will delve into the world of C-peptide and help you navigate the complexities of this diagnostic tool.

The C-peptide test measures the levels of C-peptide, a protein fragment released by the pancreas during the production of insulin. Insulin is a hormone produced by the pancreas that helps regulate blood sugar levels. When the pancreas releases insulin, it also releases a byproduct called C-peptide. The level of C-peptide is directly proportional to the amount of insulin being produced.

What is the purpose of the C-peptide test?

The C-peptide test serves several purposes, including:

  • Diagnosing and monitoring pancreatic function, particularly in cases of insulinoma (a rare tumor of the pancreas that produces excess insulin).
  • Assessing the effectiveness of insulin therapy in patients with diabetes.
  • Diagnosing and monitoring conditions such as pancreatitis (inflammation of the pancreas) or pancreatic trauma.
  • Monitoring the progress of patients undergoing pancreatic surgery.

How is the C-peptide test performed?

The C-peptide test is typically performed by drawing a blood sample from a vein in the arm. The blood is then sent to a laboratory for analysis. The test is usually performed after an overnight fast, when insulin levels are at their lowest. Low Blood Sugar Without Diabetes A Guide To Reactive Hypoglycemia And Insulinoma

What do C-peptide test results mean?

C-peptide test results are usually reported in nanograms per milliliter (ng/mL). The normal range for C-peptide is between 0.7 and 2.2 ng/mL. However, the normal range can vary depending on the laboratory and the individual's clinical context.

  • Low C-peptide levels may indicate:
    • Insulin deficiency (e.g., type 1 diabetes)
    • Pancreatic damage or dysfunction
  • High C-peptide levels may indicate:
    • Insulinoma (a rare tumor of the pancreas)
    • Pancreatitis (inflammation of the pancreas)

What are the implications of C-peptide test results?

C-peptide test results can have significant implications for patients with diabetes and those undergoing pancreatic surgery. For patients with diabetes, high C-peptide levels may indicate that their insulin therapy is effective, while low C-peptide levels may indicate the need for adjustment in their insulin regimen. For patients undergoing pancreatic surgery, high C-peptide levels may indicate the presence of insulinoma, while low C-peptide levels may indicate pancreatic damage. The Link Between Sleep Apnea And High Morning Blood Sugar

How to prepare for the C-peptide test?

To prepare for the C-peptide test, patients should:

  • Fast overnight before the test
  • Avoid strenuous exercise before the test
  • Inform their healthcare provider about any medications they are taking
  • Follow their healthcare provider's instructions regarding the test

By understanding the C-peptide test, patients can better navigate the complexities of this diagnostic tool and make informed decisions about their healthcare. If you have any questions or concerns about the C-peptide test, be sure to discuss them with your healthcare provider. Normal Blood Sugar Ranges On A Ketogenic Diet

References and Further Reading